National Collaborating Centre for Infectious Diseases / Centre de collaboration nationale des maladies infectieuses

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Susceptibility of Solvent Users to HIV and Hepatitis C

Inhalation of widely available volatile substances for their unintended psychoactive effects is gaining
prominence and is clearly a concern for public health practitioners and policy makers. This paper is
the second of a two-part mini-series that explores the association between solvent use and the increased susceptibility to HIV and other sexually transmitted and bloodborne infections (HIV/STBBIs).

The last paper presented some epidemiological data on the prevalence of solvents use in Canada and the U.S., and evidence of an association between solvent use and HIV/STBBIs. This current paper  discusses potential biological mechanisms that may be contributing to the observed phenomena of
increased susceptibility to and progression of HIV and HCV in solvent users.

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